A case of nivolumab-induced isolated adrenocorticotropic hormone (ACTH) deficiency
نویسندگان
چکیده
منابع مشابه
Isolated Adrenocorticotropic Hormone (acth) Deficiency Associated with Hashimoto's Disease
Isolated ACTH deficiency (IAD) is a rare disease which is characterized by secondary adrenal insufficiency with low cortisol production and normal secretion of pituitary hormones other than ACTH. Isolated ACTH deficiency has rare association with Hashimoto’s disease which is characterized by autoimmune origin. This suggests the possibility of common autoimmune process affecting both the pituita...
متن کامل[A case of isolated adrenocorticotropic hormone (ACTH) deficiency associated with severe hyponatremia and an empty sella].
概要 症例 は56才,男 性.54才 時 よ り食欲不 振が 出現,昭 和59年,低Na血 症 にて入院.昭 和60 年4月 よ り悪 心,嘔 吐 出現 し当科 紹介.血 清Naの 最低値は105mEq/1.血 中コ ルチ ゾール,尿 中17-OHCSの 著 しい基 礎低値.血 漿ACTH基 礎 値 は測定 感度 以下 で,イ ンス リン低 血糖, L8-V,CRFに 無反 応.他 の下垂体前 葉ホル モ ン正常.ACTH単 独 欠損症 と診 断,画 像診 断上empty sellaが確認 された.低Na血 症下 のACTH-Z負 荷 にてコルチ ゾール,17-OHCSLは 増加 し,自 由 水 ク リア ラ ンス は一0.85~ 一0.95m1/分 よ りほぼ0に 至 り,低Na血 症 は改善, ADHは1.4→0.5 pg/mlと 低下 した.本 例 の低Na血 症 に はグルコ...
متن کاملPrimary hypothyroidism and isolated ACTH deficiency induced by nivolumab therapy
RATIONALE Nivolumab is a monoclonal IgG antibody blocking programmed death receptor-1 (PD1), leading to restoration of the natural T-cell-mediated immune response against the cancer cells. However, it also causes plenty of autoimmune-related adverse events, which often involves endocrine system. PATIENT CONCERNS A 54-year-old male with renal clear cell carcinoma was treated with nivolumab int...
متن کاملThyroid dysfunction in isolated adrenocorticotropic hormone (ACTH) deficiency: case report and literature review.
A case of isolated ACTH deficiency accompanying transient primary hypothyroidism was reported along with a review of literature on isolated ACTH deficiency in Japan with special reference to its association with thyroid function. Our case, a 56-year-old woman, developed somnolence and hypoglycemia due to isolated ACTH deficiency. She also had the features of hypothyroidism, namely mounding phen...
متن کاملIsolated Adrenocorticotropic Hormone Deficiency Caused by Nivolumab in a Patient with Metastatic Lung Cancer
Nivolumab has promising efficacy for treating various advanced malignant tumors, although it has been reported to induce a wide range of autoimmune adverse effects. We herein report the case of a patient with metastatic lung adenocarcinoma who developed adrenal insufficiency after 12 cycles of nivolumab treatment. Endocrine test results supported a diagnosis of isolated adrenocorticotropic horm...
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ژورنال
عنوان ژورنال: Respiratory Medicine Case Reports
سال: 2019
ISSN: 2213-0071
DOI: 10.1016/j.rmcr.2019.01.021